![]() Nucleotide excision repair-defective xeroderma pigmentosum cells were sensitized up to 1000-fold, implicating bulky DNA photoproducts in the lethal effect. ![]() 4-thiothymidine induced UVA dose enhancements of around 100-fold in DNA repair-proficient cells. It does not induce MMR-related toxicity, but it interacts synergistically with UVA light and dramatically sensitizes cultured human cells to very low, nonlethal UVA doses. We report here that the thiopyrimidine nucleoside 4-thiothymidine is incorporated into DNA. ![]() In addition to these direct cytotoxic effects, DNA thiobases have distinctive photochemical properties, the therapeutic potential of which has not been extensively evaluated. Their toxicity requires active DNA mismatch repair (MMR), and thiopurine resistance is an acknowledged phenotype of MMR-defective cells. The thiopurines, 6-thioguanine and 6-mercaptopurine, are antileukemic agents that are incorporated into DNA following retrieval by the purine salvage pathway (see for a review). Photoactivation of DNA thiobases as a potential novel therapeutic option. ![]() Massey, Andrew Xu, Yao-Zhong and Karran, Peter ![]()
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![]() ![]() ![]() Compression can sometimes even be as efficient as 50% file size! When Ableton creates a Live Pack it also compresses the files within the pack. The easiest way to do this is with an Ableton Live Pack.Ĭopy your rack presets to the current project folder, then follow the instructions below and you’re ready to share! Archiving your finished Ableton project files If you’re like us, you like to share your custom instruments and kits with other Ableton users. Sharing custom drum racks or sampler instruments alp file is much more transfer friendly than a zipped session folder is (see below). Once the second artist is finished working on the project, they can create another Ableton Live Pack to send back. As long as both artists run the same version of Ableton and use the same plugins. Live Packs allow artists to share complete Ableton Live sessions with each other. Archiving your finished Ableton project files.Sharing custom drum racks or sampler instruments. ![]() Collaboration with other Ableton artists.Here are some reasons for creating Ableton Live Packs Live Packs are able to collect all of the files included in your session and then share a 100% complete version of it with another computer. These are basically a zipped up version of your current session. You can share anything from a full completed live session to just a single drum rack preset. Ableton has made sharing and collaborating with other Ableton users a breeze. ![]() ![]() Our intelligent, left-leaning content is guaranteed to make you laugh, or your money back. Each issue brings 24 ad-free pages with over 100 cartoons and articles, right to your doorstep. ![]() Now they are going to become even esier to find. Funny Times is a monthly cartoon and humor newspaper for a world gone weird. There are already plenty of videos like that on YouTube. 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Updated by Michael Llewellyn on January 09, 2021: The sport of MMA has grown from a niche combat sport to a mainstream entertainment medium that in many ways has overtaken boxing and even the WWE. UFC Undisputed 2010 (also known as UFC Undisputed 2) is a mixed martial arts fighting game featuring Ultimate Fighting Championship (UFC) properties and fighters developed by Yukes and published by THQ in 2010 for the PlayStation 3, Xbox 360, and (for the first time) PlayStation Portable.It is the second game to be released under THQs 2007 agreement with the UFC and it is a sequel to the. RELATED: EA's UFC 4: The 10 Best Strikers In The Game It is not surprising then that there is an equally terrible number of UFC and MMA videogames as there are good ones. Not only do developers have to make sure the stand-up works but the ground game featuring transitions, submissions, and grappling needs to be as close to the excitement of a big fight as possible. 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Bejeweled Twist, Bejeweled Blitz, Bejeweled Starsīejeweled is a series of tile-matching puzzle video games created by PopCap Games. ![]() ![]() ![]() Because of that, prices for certain pianos will always be higher than others regardless of the age and condition of the instrument. People associate a certain quality in performance and craftsmanship with certain piano brands. It’s the same in the piano business, as branding speaks highly to an instruments reputation. Like any product, the name on the label matters. Let’s start by discussing how piano branding and marketing affect prices. With that knowledge, it’s much easier to walk into a piano showroom or private seller and purchase an instrument. Brandīefore purchasing any piano, it’s important to understand the various factors that affect the price. This piano price chart shows the average cost for uprights, baby grands, and concert grands from each company. Here is a helpful pricing guide below of the 11 most popular piano brands. 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